Details
| Name | OPTN |
| Type | gene |
| Species | Mouse |
| Tissue | osteoclast |
| Experiment Method | qRT-PCR,Western blotting |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | qRT-PCR, and Western blotting indicated that OPTN deficiency reduced the basal expression of Nrf2, inhibited the expression of NRF2-responsive antioxidants, and increased basal and RANKL-induced intracellular ROS levels, leading to enhanced osteoclastogenesis. |
| Regulation Gene | Nrf2 |
| Year | 2021 |
| Pubmed ID | 33864025 |
| Title | Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response |
| Drug | NA |
| Disease | Pagets disease of bone (PDB) |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |