| Funtion Description |
Figure2 shows that transcription of the H2ax, Cdkn1a and Glb1 genes increased in the Serpinf1-/- RPE, but no increase was observed for the Trp53 gene. The H2ax levels of the Serpinf1+/- and Serpinf1-/- RPE were of 1.3-fold and 1.6-fold, respectively, of the Serpinf1+/+ littermate control. The Cdkn1a levels of the Serpinf1+/- and Serpinf1-/- RPE were both 1.3-fold of the Serpinf1+/+ littermate control. Finally, the Glb1 levels of the Serpinf1+/- and Serpinf1-/- RPE were 1.1-fold and 1.6-fold, respectively, of the Serpinf1+/+ littermate control. Serpinf1 deletion increased senescence-associated gene expression in the RPE.
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