| Funtion Description |
As shown in Fig. 5a, ERG-silenced HLMECs failed to organize themselves into vascular networks compared to those treated with non-targeting siRNA, confirming the angiogenic function of ERG in lung ECs. In addition, ERG silencing impaired cell-cell contact and caused vascular disassembly as shown in Fig. 5b. Finally, the qPCR analysis demonstrated that ERG silencing in human lung ECs reduced the expression of genes involved in angiogenesis and vascular remodeling thereby recapitulating the gene expression signature of aged mouse lung ECs (Fig. 5c).
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