A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name Dcn
Type gene
Species Mouse
Tissue patellar tendon
Experiment Method other
Up/Down NA
Pro/Anti Pro
Funtion Description I-Dcn-/- tendons had an increased midsubstance modulus at 300d (Fig. 2A) compared to WT and I-Dcn-/-/Bgn-/-. Stress-relaxation tests performed at 3 % strain found decreased relaxation in I-Dcn-/- tendons compared to WT and I-Dcn-/-/Bgn-/- at 300d (Fig. 2E), and I-Dcn-/-/Bgn-/- had increased relaxation compared to WT at 570d (Fig. 2F). However, there was a significant interaction between genotype and age during the stress-relaxation tests performed at 3 % strain. At 4 % strain I-Dcn-/-/Bgn-/- showed increased relaxation compared to I-Dcn-/- at 300d (Fig. 2G) and increased relaxation compared to WT, I-Dcn-/-, and I-Bgn-/- at 570d (Fig. 2H).
Regulation Gene NA
Year 2022
Pubmed ID 35818471
Title Decorin knockdown is beneficial for aged tendons in the presence of biglycan expression.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA