| Name |
GLB1
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Human lung carcinoma A549 cell line (LKB1-deficient, p16-deficient, p53-proficient);A549 cells
|
| Experiment Method |
RNA interference;quantitative PCR; quantitative RT-PCR;Western blot;Senescence-Associated B-galactosidase assay;Immunofluorescent Microscopy
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
GAPDH-depleted cells establish senescence phenotype, as revealed by proliferation arrest, changes in morphology, SA-B-galactosidase staining, and more than 2-fold up-regulation of senescence-associated genes DEC1 and GLB1. Accelerated senescence following
|
| Regulation Gene |
NA
|
| Year |
2011
|
| Pubmed ID |
21749859
|
| Title |
Accelerated cellular senescence phenotype of GAPDH-depleted human lung carcinoma cells.
|
| Drug |
NA
|
| Disease |
non-small cell lung cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|