Details
| Name | NEK22 |
| Type | snoRNA |
| Species | Homo sapiens |
| Tissue | hepatoma cell line SMMC-7721 and HepG2 |
| Experiment Method | NA |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | Compared with SMMC-7721 or HepG2 without knockdown of NEK2, the senescent cells of SMMC-7721 and HepG2 with knockdown of NEK2 were increased, cell proliferation and clone formation were decreased significantly, the percentage of cells in G/G phase was increased, the expression levels of phospho-Akt (p-Akt) and phospho-Rb (p-Rb) protein were decreased significantly, and the expression level of p16 protein was increased significantly (all <0.05). |
| Regulation Gene | NA |
| Year | 2022 |
| Pubmed ID | 35545405 |
| Title | NEK2 promotes the progression of liver cancer by resisting the cellular senescence. |
| Drug | NA |
| Disease | Liver cancer |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |