| Name |
hepaCAM
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
breast
|
| Experiment Method |
PCR, Flow cytometry assay, Western blot, Immunofluorescence
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Intriguingly, hepaCAM was capable of inducing cellular senescence as defined by the enlarged cell morphology and increased beta-galactosidase activity. Furthermore, hepaCAM elevated the expression levels of senescence-associated proteins including p53, p2
|
| Regulation Gene |
NA
|
| Year |
2008
|
| Pubmed ID |
18845560
|
| Title |
Expression of hepaCAM is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells
|
| Drug |
0
|
| Disease |
breast cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|