| Name |
Hes1
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
HepG2 and SNU398 HCC cell lines
|
| Experiment Method |
FACS;SDS-PAGE and Western Blot;Immunofluorescence;ChIP;SA-B-gal;Real-Time RT-PCR
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
In this study, we show that the down-regulation of Notch1 and Notch3 in two HCC cell lines resulted in Hes1 down-regulation, CDKN1C/P57 up-regulation, and reduced cell growth.Morphologically CDKN1C/p57-induced HCC cells became flat and lengthened in shape
|
| Regulation Gene |
NA
|
| Year |
2012
|
| Pubmed ID |
22705236
|
| Title |
CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma.
|
| Drug |
NA
|
| Disease |
hepatocarcinoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|