| Name |
VEGFA
|
| Type |
CNV
|
| Species |
Mus musculus
|
| Tissue |
VEGF-Ahyper mice
|
| Experiment Method |
RT-PCR and semiquantitative RT-PCR;Immunolabeling
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
Higher VEGF-A levels lead to increased oxidative stress markers and ERK hyperactivation in the aging lens and promote age-related nuclear cataract formation that can be inhibited by targeting Nlrp3 or Il1r1.Thus, reducing increased VEGF-A activity in agin
|
| Regulation Gene |
NA
|
| Year |
2016
|
| Pubmed ID |
26912740
|
| Title |
Increased VEGF-A promotes multiple distinct aging diseases of the eye through shared pathomechanisms.
|
| Drug |
NA
|
| Disease |
cataracts and both neovascular and non-exudative AMD-like pathologies
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|