Details
| Name | HMGB1 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | NA |
| Experiment Method | PCR |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | An absolute dependency of melanoma cell proliferation on HMGB1 was underscored by the marked response of cell cycle arrest and senescence to HMGB1 knockdown. |
| Regulation Gene | NA |
| Year | 2014 |
| Pubmed ID | 25051367 |
| Title | Overexpression of HMGB1 in melanoma predicts patient survival and suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent, Sp1-dependent pathway. |
| Drug | NA |
| Disease | melanoma |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |