A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name IGF1R
Type gene
Species Mus musculus
Tissue mice strains
Experiment Method qPCR
Up/Down Down
Pro/Anti Anti
Funtion Description To investigate whether IGF-1R also controls longevity in mammals, we inactivated the IGF-1R gene in mice (Igf1r). Here, using heterozygous knockout mice because null mutants are not viable, we report that Igf1r(+/-) mice live on average 26% longer than th
Regulation Gene NA
Year 2003
Pubmed ID 12483226
Title IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA