| Name |
IGFBP-6
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Two different pools of human primary diploid fibroblasts (HDFs)
|
| Experiment Method |
LC-MS/MS;Real time-PCR;Western blot and ELISA;SA-B-gal
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
When IGFBP-6 gene expression was downregulated, cell proliferation was inhibited and apoptotic cell death was increased. Furthermore, downregulation of IGFBP-6 led to premature entry into cellular senescence. Since IGFBP-6 overexpression increased cellula
|
| Regulation Gene |
NA
|
| Year |
2011
|
| Pubmed ID |
21820463
|
| Title |
Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|