| Name |
IL33
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
brain
|
| Experiment Method |
Histology and electron microscopy;Western blot;Immunofluorescence, terminal-deoxynucleotidyl-transferase dUTP nick-end labeling, immunohistochemistry and quantitation of cells on sections
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Thus, uncontrolled neuronal aging surge at middle age due to lack of IL33 resulted in neurodegeneration and late-onset AD-like symptome inIl33/mice. Our study also suggests that the aging surge is a time to search for biomarkers for early diagnosis of AD
|
| Regulation Gene |
NA
|
| Year |
2017
|
| Pubmed ID |
28675392
|
| Title |
Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|