A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name IL-6
Type gene
Species Rat Rattus
Tissue male Dark Agouti rats;Rat glomerular endothelial cells
Experiment Method SA-B-gal staining;RT-qPCR;Immunohistochemistry;Immunocytochemistry
Up/Down NA
Pro/Anti Pro
Funtion Description The irradiated kidneys showed hallmarks of cellular senescence, including increased SA-B-gal activity, upregulation of cyclin-dependent kinase inhibitor (p53, p21, and p16), and absence of DNA proliferation marker (Ki-67).Furthermore, combined with in-vit
Regulation Gene NA
Year 2018
Pubmed ID 30429495
Title Radiation-induced premature cellular senescence involved in glomerular diseases in rats.
Drug NA
Disease kidney diseases
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA