| Name |
INS
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
C2C12 myoblasts,HepG2
|
| Experiment Method |
RT-PCR,knockdown,Western Blot,other
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
SIRT1 has been reported to be involved in the processes of glucose metabolism and insulin secretion.SIRT1 is downregulated in insulin-resistant cells and tissues and that knockdown or inhibition of SIRT1 induces insulin resistance. Furthermore, increased
|
| Regulation Gene |
NA
|
| Year |
2007
|
| Pubmed ID |
17908559
|
| Title |
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|