Details
| Name | JMJD2A |
| Type | gene |
| Species | Homo sapiens |
| Tissue | Human diploid fibroblasts IMR90, WI-38, BJ, MEF, MEF p53 / , MEF p19ARF / , MCF7, A549, HeLa, 293T, and osteosarcoma cells U2OS (ATCC) |
| Experiment Method | Western Blot Analysis and Immunofluorescence;Immunohistochemistry Staining |
| Up/Down | Up |
| Pro/Anti | Anti |
| Funtion Description | JMJD2A functions as a negative regulator of Ras-induced senescence and collaborates with oncogenic Ras to promote cellular transformation by negatively regulating the p53 pathway. We find CHD5, a known tumor suppressor regulating p53 activity, as a target |
| Regulation Gene | NA |
| Year | 2012 |
| Pubmed ID | 23168260 |
| Title | JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5. |
| Drug | NA |
| Disease | osteosarcoma |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |