A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name SOD2
Type enhancer
Species Mus musculus
Tissue Human ES cell line (H9) with a stable normal (46XX) karyotype
Experiment Method Western blotting;Real-time quantitative PCR; Immunocytochemistry
Up/Down Down
Pro/Anti Pro
Funtion Description MPTP-treated NPCs were found to undergo premature senescence determined by increased senescence-associated-B-galactosidase (SA-B-gal) activity, elevated intracellular reactive oxygen species level, and decreased proliferation] and were associated with imp
Regulation Gene NA
Year 2015
Pubmed ID 26159917
Title Rejuvenation of MPTP-induced human neural precursor cell senescence by activating autophagy.
Drug 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP),rapamycin
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA