Details
| Name | LMNA |
| Type | gene |
| Species | Rabbits |
| Tissue | NA |
| Experiment Method | RT-PCR |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Here, to establish a rabbit knockout (KO) model of premature aging syndromes, we performed precise LMNA targeting in rabbits via co-injection of Cas9/sgRNA mRNA into zygotes. The LMNA-KO rabbits exhibited reduced locomotion activity with abnormal stiff |
| Regulation Gene | NA |
| Year | 2019 |
| Pubmed ID | 30705772 |
| Title | LMNA-mutated Rabbits: A Model of Premature Aging Syndrome with Muscular Dystrophy and Dilated Cardiomyopathy. |
| Drug | 0 |
| Disease | NA |
| Environment Factors | NA |
| Circulating | 1 |
| Variant | NA |
| High-throughput | NA |