| Name |
LMNA
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
AG01972 Fibroblasts
|
| Experiment Method |
ChIP,RT-PCR,Immunoblot,FISH
|
| Up/Down |
NA
|
| Pro/Anti |
NA
|
| Funtion Description |
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature-aging syndrome caused by a dominant mutation in the gene encoding lamin A(LMNA), which leads to an aberrantly spliced and processed protein termed progerin. Telomerase(TERT) extends HGPS cellular
|
| Regulation Gene |
NA
|
| Year |
2010
|
| Pubmed ID |
20605919
|
| Title |
Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
1
|
| High-throughput |
NA
|