A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name LMNA
Type gene
Species Mus musculus
Tissue NA
Experiment Method RT-PCR,Microarray
Up/Down Up
Pro/Anti Anti/Pro
Funtion Description Alternative RNA processing of LMNA pre-mRNA produces three main protein isoforms, that is, lamin A, progerin, and lamin C. De novo mutations that favor the expression of progerin over lamin A lead to Hutchinson-Gilford progeria syndrome (HGPS), providing
Regulation Gene NA
Year 2014
Pubmed ID 24639560
Title Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA