| Name |
MCL1
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
The HCT116 human colon cancer cell lines (p53+, p53, and p21);Wild-type murine embryonic fibroblasts (MEFs)
|
| Experiment Method |
Western blotting;SA-B-gal;immunohistological staining;Immunohistochemical analysis;
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
Mcl-1, a Bcl-2 family member, plays an important role in preventing chemotherapy-induced senescence (CIS). Overexpression of Mcl-1 in p53 cell lines inhibits CIS. Conversely, downregulation of Mcl-1 makes cells sensitive to CIS. Surprisingly, downregulati
|
| Regulation Gene |
NA
|
| Year |
2012
|
| Pubmed ID |
22451485
|
| Title |
Inhibition of Mcl-1 promotes senescence in cancer cells: implications for preventing tumor growth and chemotherapy resistance.
|
| Drug |
NA
|
| Disease |
colon cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|