| Name |
MTH1
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
BJ, BJ-T, BJ-LT and MRC5
|
| Experiment Method |
Immunofluorescence,Western Blot,Single-Cell Gel Electrophoresis (Comet) Assay,other
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
We devised a strategy to decouple levels of 8-oxoguanine, a major oxidative DNA lesion, from ROS levels. Suppression of MTH1 expression, which hydrolyzes 8-oxo-dGTP, was accompanied by increased total cellular 8-oxoguanine levels and caused early-passage
|
| Regulation Gene |
NA
|
| Year |
2009
|
| Pubmed ID |
19118192
|
| Title |
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|