Details
| Name | mTORC1/RAPTOR |
| Type | gene |
| Species | Homo sapiens |
| Tissue | human disc NP;Monolayer |
| Experiment Method | Western blot |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | In senescence, IL-1B-induced senescence-associated beta-galactosidase (SA-B-gal)-positive cells and p16/INK4A expression also decreased by RAPTOR RNAi. In matrix metabolism, RAPTOR RNAi reduced IL-1B-induced catabolic matrix metalloproteinase (MMP) releas |
| Regulation Gene | NA |
| Year | 2017 |
| Pubmed ID | 28888905 |
| Title | Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |