| Name |
MYCN
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Erythroleukemia cell lines HEL and K562, M2 cell line Kasumi-1 and M5 cell line THP1
|
| Experiment Method |
qRT-PCR;Intracellular flow cytometry assay;proliferation assay;Colony formation assay;Cell cycle analysis;Human Gene Expression Array;ChIP assay and ChIP-qPCR
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
In this study, we found that the patients with erythroleukemia showed higher expression of MYCN than normal controls.In vitroexperiments, knockdown of MYCN resulted in decreased cell proliferation, elevated autonomously cell apoptosis and increased P21-me
|
| Regulation Gene |
NA
|
| Year |
2017
|
| Pubmed ID |
29022893
|
| Title |
MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-mediated epigenetic repression of p21
|
| Drug |
NA
|
| Disease |
erythroleukemia
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|