| Name |
NEK4
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Human foreskin fibroblasts (HFF);293T cells
|
| Experiment Method |
Immunoblotting, immunoprecipitation (IP), and reverse transcription (RT)-PCR;SA B-Gal;Immunofluorescence
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
NEK4 disrupted timely entry into senescence.NEK4 suppression extended the number of population doublings required to reach replicative senescence in several human fibroblast strains and resulted in decreased transcription of the cyclin-dependent kinase in
|
| Regulation Gene |
NA
|
| Year |
2012
|
| Pubmed ID |
22851694
|
| Title |
Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|