A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name NF-kB
Type gene
Species Mus musculus
Tissue liver,gut
Experiment Method qPCR,immunofluorescence,western blot, ImmunoFISH
Up/Down Down
Pro/Anti Anti
Funtion Description Chronic inflammation is associated with normal and pathological ageing. Here we show that chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of the transcription factor NF-kB induces premature ageing in mice. We also show
Regulation Gene NA
Year 2014
Pubmed ID 24960204
Title Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA