| Name |
Notch3
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
NA
|
| Experiment Method |
RT-PCR
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Downregulation of Notch3 led to a delayed onset of senescence and extended replicative lifespan, whereas adventitious expression of Notch3 was sufficient to activate senescence and p21 expression.
|
| Regulation Gene |
NA
|
| Year |
2013
|
| Pubmed ID |
23610446
|
| Title |
Notch3 functions as a tumor suppressor by controlling cellular senescence.
|
| Drug |
NA
|
| Disease |
breast cancer,melanoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
GSE3165,GSE3189 and GSE7553
|