Details
| Name | Nrf2 |
| Type | gene |
| Species | Dog |
| Tissue | cADMSCs |
| Experiment Method | Western blot;Immunocytochemistry;Dual-luciferase assay;Quantitative real-time PCR;Senescence associated B-galactosidase staining |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | We found that melatonin alleviates endoplasmic reticulum stress (ERS) and cell senescence. MT1/MT2 melatonin receptor inhibitor, luzindole, diminished the mRNA expression levels and rhythm expression amplitude of Bmal1 and Nrf2 genes.These results indicat |
| Regulation Gene | NA |
| Year | 2018 |
| Pubmed ID | 30362962 |
| Title | Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |