Details
| Name | p16INK4a |
| Type | gene |
| Species | Rat Rattus |
| Tissue | rat intestinal epithelial crypt cell line IEC-6 (52) |
| Experiment Method | Western blot |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | Constitutive activation of MEK in IECs can produce either premature senescence or forced mitogenesis depending on the integrity of a senescence program controlled by the cell cycle inhibitors p53, p16(INK4A), and p22(CIP). |
| Regulation Gene | NA |
| Year | 2004 |
| Pubmed ID | 14701721 |
| Title | Dual role of MEK/ERK signaling in senescence and transformation of intestinal epithelial cells. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |