| Name |
p16INK4a
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
NA
|
| Experiment Method |
qRT-pCR, Immunofluorescence
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
p16Ink4a is a potent cell cycle inhibitor engaged to support cell cycle arrest during cellular senescence. We observed that p16Ink4a-overxpressing murine sarcoma cells were resistant to ABT-263 and ABT-737, anti-cancer small molecules previously shown to
|
| Regulation Gene |
NA
|
| Year |
2018
|
| Pubmed ID |
29484109
|
| Title |
A novel suicide gene therapy for the treatment of p16Ink4a-overexpressing tumors
|
| Drug |
ABT-263, ABT-737
|
| Disease |
tumor
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|