| Name |
p21
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Human myometrial and leiomyoma tissues
|
| Experiment Method |
Senescence-associated B-galactosidase (SA-B-gal) staining; SDS-PAGE and Western blotting;RNA isolation and RT-PCR; Immunohistochemistry
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
HMGA2 tumors had significantly higher levels of AKT signaling and mitogenic activity than other ULM types. HMGA2 activated AKT signaling through upregulation of IGF2BP2. Silencing HMGA2 in ULM cells resulted in downregulation of AKT and upregulation of p1
|
| Regulation Gene |
NA
|
| Year |
2018
|
| Pubmed ID |
29790226
|
| Title |
Comparative analysis of AKT and the related biomarkers in uterine leiomyomas with MED12, HMGA2, and FH mutations.
|
| Drug |
NA
|
| Disease |
uterine leiomyoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|