| Name |
p21
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Human breast cancer MCF-7 and Hs578T cells
|
| Experiment Method |
Western blotting;SA-b-gal;Flow cytometry assay
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
IGFBP-rP1-induced growth arrest is associated with enhanced expression of the cyclin-dependent kinase inhibitor p21 and dephosphorylation of the retinoblastoma protein (pRB). Cell proliferation block and cellular senescence induction in response to IGFBP-
|
| Regulation Gene |
NA
|
| Year |
2012
|
| Pubmed ID |
22392074
|
| Title |
IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells.
|
| Drug |
NA
|
| Disease |
breast cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|