| Name |
p21
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
The normal human mammary epithelial cell line H184B5F5/M10;HeLa, SW-13, Hs68, NIH3T3, p53+/+, and p53/ MEF cells
|
| Experiment Method |
Senescence SA-B-gal staining;Western Blot, Coimmunoprecipitation, Immunofluorescence, Luciferase Assays, and Real Time Quantitative PCR (qPCR);ChIP;Yeast Two-hybrid;IHC
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
First, MSP58 activates the DNA damage response and p53/p21 signaling pathways. Second, MSP58, p53, and the SWI/SNF chromatin-remodeling subunit Brahma-related gene 1 (BRG1) form a ternary complex on the p21 promoter and collaborate to activate p21. Additi
|
| Regulation Gene |
NA
|
| Year |
2012
|
| Pubmed ID |
22563078
|
| Title |
58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|