Details
| Name | p21 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | Huh-7 hepatoma cells |
| Experiment Method | Western blot |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | Ninjurin1-overexpressing clones exhibited strong growth inhibition due to G1 cell cycle arrest, which is associated with a posttranscriptional increase in p21WAF1/Cip1, a decrease of cyclin-dependent kinase 2 activity and the hypophosphorylation of Rb. |
| Regulation Gene | NA |
| Year | 2004 |
| Pubmed ID | 15464245 |
| Title | Ninjurin1 increases p21 expression and induces cellular senescence in human hepatoma cells. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |