| Name |
p21(waf1)
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Human primary fibroblasts (IMR90 passage 12, ATCC);; MCF10A cells
|
| Experiment Method |
RNA interference;Real-time RT-PCR;Western blotting;Immunofluorescence microscopy;SA-bGal
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
To this aim we depleted Mad2 by RNAi to a level shown by Mad2 haplo-insufficient cells and found that induced aneuploidy caused premature cellular senescence in IMR90 cells.IMR91 cells showed typical features of senescent cells, like senescence-associated
|
| Regulation Gene |
NA
|
| Year |
2012
|
| Pubmed ID |
22170163
|
| Title |
MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p54 pathway preventing aneuploid cells propagation.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|