| Name |
p21Waf1 / Cip1
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
HeLa, A549 and WI-38 cells;Saos-2 cells
|
| Experiment Method |
RT-PCR;Western blot;SA-b-Gal;Luciferase reporter assay
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
We further showed that the inactivation of DP1, but not DP2, resulted in mRNA induction for p53, an upstream regulator of p21Waf1/Cip1. Furthermore, in A549 lung cancer cells as well as HeLa cells, the mRNA and protein levels of p53 and p21Waf1/Cip1 were
|
| Regulation Gene |
NA
|
| Year |
2012
|
| Pubmed ID |
22012588
|
| Title |
Acute loss of DP1, but not DP2, induces p53 mRNA and augments p21Waf1/Cip1 and senescence.
|
| Drug |
NA
|
| Disease |
cervical cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|