| Name |
p27
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
The human breast cancer cell lines MCF-7 and MDA-MB-231, lung cancer cell line H1299 and normal breast epithelial cell line MCF-10A
|
| Experiment Method |
MTT;EdU;SA-B-gal staining;JC-1 staining;Quantitative real-time PCR; Western blotting
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
This reveals that resveratrol induced cancer cellular senescence through DLC1 in a ROS-dependent manner. Silencing DLC1 markedly attenuated SA-B-gal activity and p38MAPK, p27 and p21 protein levels, and increased Rb expression, indicating that resveratrol
|
| Regulation Gene |
NA
|
| Year |
2018
|
| Pubmed ID |
29964052
|
| Title |
Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|