| Name |
p27
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Human embryonic lung diploid fibroblast 2BS cells;Human embryonic lung diploid fibroblast WI38 cells;HeLa cells
|
| Experiment Method |
siRNA Transfection;Immunoblot;Reverse Transcription-PCR;SA-B-gal;Co-immunoprecipitation
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
Here, we show that the expression patterns of p27(Kip1) and WWP1 are inversely correlated during cellular senescence. Moreover, the overexpression of WWP1 delayed senescence, whereas the knockdown of WWP1 led to premature senescence in human fibroblasts.
|
| Regulation Gene |
NA
|
| Year |
2011
|
| Pubmed ID |
21795702
|
| Title |
WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|