| Name |
p27
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Lung adenocarcinoma cell lines A549, H292 and H1299
|
| Experiment Method |
Transfection of siRNA;real time PCR;Western Blot;Senescence associated-B-galactosidase staining
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Extended Dex treatment induces irreversible cell cycle blockade and a senescence phenotype through chronic activation of the p27Kip1 gene in GR overexpressing lung tumor cell populations and hence could improve outcome of surgery/pemetrexed chemotherapy a
|
| Regulation Gene |
NA
|
| Year |
2018
|
| Pubmed ID |
30375484
|
| Title |
Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor.
|
| Drug |
Dexamethasone
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|