| Name |
p53
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
Female Alpl+/+, Alpl+/- and AlplCre/+; Rosa26mTmG/+mice;Female immunocompromised nude 2- and 24-month-old mice;Female SAMPR1 and SAMP6 mice
|
| Experiment Method |
Immunofluorescent staining;Immunohistochemistry;Senescence-associated B-galactosidase staining;TRAP staining;ELISA assay;qRT-PCR;Flow cytometric analysis;Western blotting
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Here, we determined that ablation of Alpl induces prototypical premature bone ageing characteristics, including bone mass loss and marrow fat gain coupled with elevated expression of p16INK4A (p16) and p53 due to senescence and impaired differentiation in
|
| Regulation Gene |
NA
|
| Year |
2018
|
| Pubmed ID |
30210899
|
| Title |
Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells.
|
| Drug |
metformin
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|