Details
| Name | p53 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | HEK293T,;U87MG;Ln229 |
| Experiment Method | PCR |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | Misfolding mutations in the DNA-binding domain of p53 alter its conformation, affecting the efficiency with which it binds to chromatin to regulate target gene expression and cell cycle checkpoint functions in many cancers, including glioblastoma. Small m |
| Regulation Gene | NA |
| Year | 2018 |
| Pubmed ID | 29765555 |
| Title | A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |