| Name |
p53
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
breast
|
| Experiment Method |
Flow cytometry assay, Western blot, Immunofluorescence
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
we demonstrated that GON triggers the appearance of a wild-type-like p53 protein by using conformation-specific antibodies, immunoprecipitation, DNAbinding assays and target gene expression. p53 restoration was associated with a G2/M arrest, senescence,
|
| Regulation Gene |
NA
|
| Year |
2018
|
| Pubmed ID |
30010803
|
| Title |
Selective killing of human breast cancer cells by the styryl lactone (R)-goniothalamin is mediated by glutathione conjugation, induction of oxidative stress and marked reactivation of the R175H mutant p53 protein
|
| Drug |
R-goniothalamin (GON)
|
| Disease |
breast cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|