A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name p53
Type gene
Species Homo sapiens
Tissue normal human diploid fibroblast
Experiment Method qPCR
Up/Down NA
Pro/Anti Pro
Funtion Description Here, we characterize the p53-dependent G1 arrest in several normal human diploid fibroblast (NDF) strains and p53-deficient cell lines treated with 0.1-6 Gy gamma radiation. DNA damage and cell cycle progression analyses showed that NDF entered a prolong
Regulation Gene NA
Year 1994
Pubmed ID 7958916
Title DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA