A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name p53
Type gene
Species Homo sapiens
Tissue human diploid fibroblasts
Experiment Method Western Blotting;qPCR
Up/Down Down
Pro/Anti Anti
Funtion Description After the empty vector-transfected controls had become senescent and positive for senescence-associated beta-galactosidase (SA-beta-gal), the mot-2-expressing cells continued to proliferate for an additional 12-18 population doublings and showed a young c
Regulation Gene NA
Year 2000
Pubmed ID 10838077
Title Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA