A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name p53
Type gene
Species Homo sapiens
Tissue WI38 human lung fibroblasts
Experiment Method immunoblotting
Up/Down Up
Pro/Anti Pro
Funtion Description Finally, we provide evidence that PML(promyelocytic leukemia) IV-induced senescence involves stabilization and activation of p53 through phosphorylation at Ser46 and acetylation at Lys382, and that it occurs independently of telomerase and differs from th
Regulation Gene NA
Year 2002
Pubmed ID 12093737
Title Deconstructing PML-induced premature senescence.
Drug NA
Disease promyelocytic leukemia
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA