Details
| Name | p53 |
| Type | gene |
| Species | Mus musculus |
| Tissue | mouse embryonic fibroblasts |
| Experiment Method | immunoblotting |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Haploid loss of p53 overcame embryonic senescence but failed to prevent the adult mutant mice from prematurely aging, which included decreased life span, reduced body fat deposition, osteoporosis, skin atrophy, and decreased wound healing. |
| Regulation Gene | NA |
| Year | 2003 |
| Pubmed ID | 12533509 |
| Title | Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |