| Name |
p53
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
IMR90 normal human lung fibroblasts;EJ human bladder carcinoma cells and H1299 human lung carcinoma cells
|
| Experiment Method |
Senescence associated (SA)-B-galactosidase staining;Semi-quantitative RT-PCR;Western blot
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
Interestingly, the enforced expression of Nek6 in EJ and H1299 cells completely suppresses p53-induced senescence, whereas the expression of kinase-dead Nek6 did not affect p53-induced senescence. Mechanistic studies revealed that cell cycle arrest in the
|
| Regulation Gene |
NA
|
| Year |
2010
|
| Pubmed ID |
21099361
|
| Title |
Nek6 overexpression antagonizes p53-induced senescence in human cancer cells.
|
| Drug |
NA
|
| Disease |
bladder cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|