| Name |
p53
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Normal human keratinocytes;Human dermal fibroblasts (donor age 9; passage 4; Welskin) and human keratinocyte-derived cells (HaCaT; Korean Cell Line Bank, Seoul, Korea)
|
| Experiment Method |
Western blot;Senescence-associated B-galactosidase (SA B-Gal)
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Here, we show that an increased expression of AR in human keratinocytes modulates UVB-induced apoptotic cell death and senescence. Overexpression of AR in HaCaT cells significantly attenuated UVB-induced cellular damage and apoptosis, with a decreased gen
|
| Regulation Gene |
NA
|
| Year |
2011
|
| Pubmed ID |
21182935
|
| Title |
Aldose reductase in keratinocytes attenuates cellular apoptosis and senescence induced by UV radiation.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|