| Name |
p53
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
HeLa cells, A375, 293 and U2OS cells
|
| Experiment Method |
RNA interference;senescence-associated B-galactosidase;Immuno-fluorescence microscopy;Western blot
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
Here we show that depletion of Tpr by RNA interference triggers G0-G1 arrest and ultimately induces a senescent-like phenotype dependent on the presence of p53. We also found that Tpr depletion impairs the NES [nuclear export sequence]-dependent nuclear e
|
| Regulation Gene |
NA
|
| Year |
2011
|
| Pubmed ID |
21811608
|
| Title |
Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cells.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|