| Name |
p53
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
humanprostate cancer cell line DU145 (HTB81), breast adenocarcinoma cell lines MCF-7 (HTB-22) and MDA-MB-468 (HTB-132), and hepatocellular carcinoma cell lines Hep-G2 (HB8065) and Hep-3B (HB-8064)
|
| Experiment Method |
PCR, Luciferase reporter assay
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Here, we showed that sPDZD2 induced senescence of prostate cancer DU145 cells, quiescence of breast cancer MCF-7 and liver cancer Hep-G2 cells, via transcriptional activation of mutant or wild-type p53. Furthermore, sPDZD2 sensitized mutant p53-positive D
|
| Regulation Gene |
NA
|
| Year |
2008
|
| Pubmed ID |
18639375
|
| Title |
The autocrine human secreted PDZ domain-containing protein 2 (sPDZD2) induces senescence or quiescence of prostate, breast and liver cancer cells via transcriptional activation of p53
|
| Drug |
0
|
| Disease |
prostate cancer, breast adenocarcinoma, hepatocarcinoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|